The H.265/MPEG-HEVC is the latest video coding standard, which achieves an increase of about 50% in coding efficiency compared to its predecessor H.264/MPEG-AVC. Ever since H.265/MPEG-HEVC was designed to replace almost all existing H.264/ MPEG-AVC codecs, high-resolution video coding beyond High Definition (4K, 8K, etc.) has drawn more attention. On the other hand, it’s well known that reference implementation of HEVC codec, HM, acts an important role during standardization, particularly for evaluation of rate distortion performance of different tools. However, HM is far from a practical codec because of very slow coding speed even on modern multi-core computers. Up to now except for HM few comparisons are known about both the coding performance and the coding speed of practical HEVC encoders for high resolution video sequences. To address this issue, this paper conducts a comprehensive evaluation of latest high performance H.265/MPEG-HEVC encoders, including the open source encoder—x265 and the commercial encoder—DivX265, based on default parameters and a new open 4K video database. Furthermore, latest HM and x264 are also included for performance anchors. The experimental results show DivX265 provides average bit-rate savings of 4.79% relative to HM while x265 with default preset achieves an average reduction of 3.21% in terms of BD-BR saving. In addition, different presets of x265 make a good tradeoff between coding speed and R-D performance while DivX265 is almost as fast as x265 ultrafast preset. We believe such evaluation information could provide a more comprehensive picture of state-of-the-art H.265/MPEGHEVC encoders.